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1994-09-05
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Document 0843
DOCN M9480843
TI A similar microbiologic profile in HIV-seropositive (HIV+) and
seronegative (HIV-) women with pelvic inflammatory disease (PID).
Multicenter HIV and PID Study Group.
DT 9410
AU Moorman A; Rice R; Irwin K; O'Sullivan M; Sperling R; Brodman M; Droese
A; CDC, Atlanta, GA.
SO Abstr Gen Meet Am Soc Microbiol. 1994;94:553 (abstract no. C-356).
Unique Identifier : AIDSLINE ASM94/94313102
AB To compare the microbiologic findings in HIV+ women with PID who may be
immunosuppressed with those in HIV- women with PID, we started a
prospective study in 1992 at two urban hospitals to evaluate women who
have had PID diagnosed using standard criteria. Vaginal and endocervical
secretions and endometrial biopsy tissue were tested for bacteria,
viruses, and fungi, including common etiologic agents of PID.
Preliminary data indicate that endometritis, based on standard
histopathologic criteria, is significantly more common in HIV+ than HIV-
women (HIV+ 7/10(70%), HIV- 17/55(31%), p < .05). HIV+ women tested to
date were more likely than HIV- women to have endocervical human
papilloma virus (HPV), including types associated with dysplasia (HIV+
5/13(38%), HIV- 9/61(15%), p = .06). There were no significant
differences between HIV+ and HIV- women in bacteria or fungi recovered
from the vagina, cervix, or endometrium: endocervical gonorrhea, HIV+
7/20(35%), HIV- 27/89(30%); endometrial gonorrhea, HIV+ 4/17(24%), HIV-
20/77(26%); endocervical chlamydia culture, HIV+ 2/11(18%), HIV-
11/67(16%); endocervical chlamydia DFA, HIV+ 5/17(29%), HIV- 18/81(22%);
endometrial chlamydia, HIV+ 1/10(10%), HIV- 5/58(9%); endometrial
facultative bacteria, HIV+ 9/16(56%), HIV- 54/74(72%); endometrial
anaerobic bacteria, HIV+ 0/16, HIV- 10/76(13%). Preliminary data
indicate that the microbiologic findings in HIV+ and HIV- women with PID
appear similar. Our data do not suggest a need for changes in standard
antibiotic treatment, but highlight the need for PAP smear screening for
HPV cytologic changes.
DE Adnexitis/EPIDEMIOLOGY/*MICROBIOLOGY Bacteria/ISOLATION & PURIF Cervix
Uteri/MICROBIOLOGY Chlamydia Infections/EPIDEMIOLOGY Comparative Study
Endometrium/MICROBIOLOGY Female Fungi/ISOLATION & PURIF
Gonorrhea/EPIDEMIOLOGY Hospitals, Urban Human *HIV Seronegativity
HIV Seropositivity/*MICROBIOLOGY Prospective Studies
Vagina/MICROBIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).